Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 16 Reviews
8.1
Supplement Facts
Serving Size: 2 Enteric Coated Softgels
Amount Per Serving
%DV
Calories
25
Total Fat
2.5 g
4%†
Cholesterol
<5 mg
2%†
Pure+™ Wild Fish Oil ConcentrateYielding: EPA (eicosapentaenoic acid)DHA (docosahexaenoic acid)
2,000 mg700 mg500 mg
******
Polyphen-Oil™ Olive extract (fruit and leaf)[providing 19.5 mg polyphenols, 5.2 mg hydroxytyrosol/tyrosol, 4.4 mg verbascoside/oleuropein]
300 mg
**
Sesame seed lignan extract
10 mg
**
Top Medical Research Studies
9
We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
Read More
8
We investigated how eicosapentaenoic acid (EPA) affects heart rhythm, particularly in the context of high-fat diets. In our study, mice were divided into two groups: one received a high-fat diet, while the other’s diet was supplemented with EPA for eight weeks.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
Read More
9
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Read More
Most Useful Reviews
9
Improved heart function
1 people found this helpful
An excellent supplement for bolstering heart health, enhancing cognitive function, and reducing inflammation. I’m pleased with the outcomes and will continue its use. I recommend it for improving cardiovascular health; I’ve noticed an enhancement in heart function and an overall feeling of alertness, alongside better concentration. After a few weeks, my heart function improved, and I experienced less fatigue post-exercise.
Read More
9
Supports heart health
2 people found this helpful
The quality of this omega is top-notch, made from fish caught in natural waters, with purity certificates available. It’s enriched with polyphenols from olive leaves and sesame extract, providing a valuable supplement for the heart and circulation. Given the price per serving, it’s competitive with basic omega options. I’ll update my review after a month of use.
Read More
8
Vital compounds identified
1 people found this helpful
This product is wonderful; Omega-3 is essential, especially the compounds ALA and DHA, which are necessary for heart and blood vessel protection. Their total should be between 1 gram and 2 grams.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
- All Researches
9
We analyzed the impact of different fatty acid-derived acylcarnitines on heart health. The study found that saturated and monounsaturated acylcarnitines, especially trans-elaidoylcarnitine, significantly impaired heart function and mitochondrial activity, leading to cardiotoxicity.
In contrast, omega-3-derived acylcarnitines, like eicosapentaenoylcarnitine and docosahexaenoylcarnitine, were found to be safe, having little to no negative effect on heart function and cell viability. Overall, this research suggests that omega-3 fatty acids may be a safer option for those facing cardiac challenges.
In contrast, omega-3-derived acylcarnitines, like eicosapentaenoylcarnitine and docosahexaenoylcarnitine, were found to be safe, having little to no negative effect on heart function and cell viability. Overall, this research suggests that omega-3 fatty acids may be a safer option for those facing cardiac challenges.
Read More
9
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Read More
9
We examined the relationship between plasma omega-3 levels and heart failure (HF), focusing on how this affects mortality in patients with existing HF. Our analysis of the UK Biobank, which included nearly 272,000 participants without HF, showed that higher omega-3 levels were linked to a 21% lower risk of developing HF over nearly 14 years.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
For those already diagnosed with HF, higher omega-3 levels significantly reduced the risk of all-cause and cardiovascular mortality by around 50%. These findings suggest that boosting omega-3 intake could be beneficial for heart health.
Read More
9
Omega-3 benefits African Americans’ heart health
We observed that the role of omega-3 fatty acids in heart health showed promising results specifically for African Americans. By comparing matched groups from the VITAL trial, we found that omega-3 supplementation significantly reduced the risk of myocardial infarction in African Americans, while no such benefit was seen in non-Hispanic whites.
This suggests that genetic or lifestyle factors may influence the effectiveness of these supplements. Our findings highlight the importance of further research to better understand how race affects responses to omega-3 supplementation.
This suggests that genetic or lifestyle factors may influence the effectiveness of these supplements. Our findings highlight the importance of further research to better understand how race affects responses to omega-3 supplementation.
Read More
8
We investigated how eicosapentaenoic acid (EPA) affects heart rhythm, particularly in the context of high-fat diets. In our study, mice were divided into two groups: one received a high-fat diet, while the other’s diet was supplemented with EPA for eight weeks.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved heart function
1 people found this helpful
An excellent supplement for bolstering heart health, enhancing cognitive function, and reducing inflammation. I’m pleased with the outcomes and will continue its use. I recommend it for improving cardiovascular health; I’ve noticed an enhancement in heart function and an overall feeling of alertness, alongside better concentration. After a few weeks, my heart function improved, and I experienced less fatigue post-exercise.
Read More
9
Supports heart health
2 people found this helpful
The quality of this omega is top-notch, made from fish caught in natural waters, with purity certificates available. It’s enriched with polyphenols from olive leaves and sesame extract, providing a valuable supplement for the heart and circulation. Given the price per serving, it’s competitive with basic omega options. I’ll update my review after a month of use.
Read More
8
Vital compounds identified
1 people found this helpful
This product is wonderful; Omega-3 is essential, especially the compounds ALA and DHA, which are necessary for heart and blood vessel protection. Their total should be between 1 gram and 2 grams.
Read More
7.5
Decreased palpitations
1 people found this helpful
I feel that my heart palpitations have lessened significantly. Indefinite complaints and headaches have also subsided. This may not be the sole reason, but given that fish is pricey and cooking is laborious, taking supplements is far more convenient for me.
Read More
7.5
High-quality fish oil
1 people found this helpful
After a lengthy search for high-quality fish oil with substantial levels of EPA and DHA, I chose Life Extension, Super Omega-3. After months of use, I’ve found it significantly beneficial. The high Omega-3 concentration is crucial for heart health, and the capsules have no fishy aftertaste. I noticed better concentration, reduced fatigue, and even improved skin. Although the capsules are large and the price is higher, the quality makes it worth it.
Read More
Frequently Asked Questions
9
Improved heart function
1 people found this helpful
An excellent supplement for bolstering heart health, enhancing cognitive function, and reducing inflammation. I’m pleased with the outcomes and will continue its use. I recommend it for improving cardiovascular health; I’ve noticed an enhancement in heart function and an overall feeling of alertness, alongside better concentration. After a few weeks, my heart function improved, and I experienced less fatigue post-exercise.
7.5
Valuable complex supplement
This omega source from wild fish boasts purity and includes beneficial olive polyphenols, making it a valuable supplement for cardiovascular health. With a fair price compared to standard omega options, it’s a wise choice for those prioritising heart and vessel support. I’ll provide more insight after a month of use.
7.5
High-quality fish oil
1 people found this helpful
After a lengthy search for high-quality fish oil with substantial levels of EPA and DHA, I chose Life Extension, Super Omega-3. After months of use, I’ve found it significantly beneficial. The high Omega-3 concentration is crucial for heart health, and the capsules have no fishy aftertaste. I noticed better concentration, reduced fatigue, and even improved skin. Although the capsules are large and the price is higher, the quality makes it worth it.
6
Supports heart function
The quality of this omega is exceptional. It includes powerful antioxidants beneficial for overall health. It supports heart function, restores cholesterol levels, reduces inflammation, and even enhances skin and hair. The taste is neutral and easy to consume. It has also improved my cognitive health significantly. I highly recommend it.
7.5
Decreased palpitations
1 people found this helpful
I feel that my heart palpitations have lessened significantly. Indefinite complaints and headaches have also subsided. This may not be the sole reason, but given that fish is pricey and cooking is laborious, taking supplements is far more convenient for me.
7.5
High EPA/DHA levels
Watch for variances in dosages among Life Extension Omega 3 variants. The enterically coated capsules lack fish taste and contain quality ingredients. Omega-3 is crucial for managing cholesterol and inflammation as we age, and the high EPA/DHA levels are rare in many products, promoting heart and mental well-being.
7.5
Boosts HDL cholesterol
1 people found this helpful
This fish oil, suitable for middle-aged users, effectively boosts HDL cholesterol for heart health. Based on my blood test results, it has proven effective. There’s no fishy taste, and it’s well-packaged to avoid waste, though I didn’t notice any hair improvement.
4
We examined how a diet deficient in omega-3 fatty acids correlates with the burden of ischemic heart disease (IHD) from 1990 to 2021.
The findings reveal a concerning association: low omega-3 intake contributed to millions of disability-adjusted life years and deaths globally, indicating a notable impact on heart health.
While some regions, like South Asia, faced a higher burden, the overall trend shows that promoting healthier diets rich in omega-3 could be pivotal in reducing heart disease risk.
The findings reveal a concerning association: low omega-3 intake contributed to millions of disability-adjusted life years and deaths globally, indicating a notable impact on heart health.
While some regions, like South Asia, faced a higher burden, the overall trend shows that promoting healthier diets rich in omega-3 could be pivotal in reducing heart disease risk.
9
We explored how omega-3 polyunsaturated fatty acids (PUFAs) can help manage heart failure by analyzing 14 randomized controlled trials involving over 9,000 participants.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
Our findings revealed that high doses—between 2000 and 4000 mg daily—taken for at least a year, remarkably improved heart function.
However, lower doses or shorter treatment periods didn’t show the same benefits. Notably, there were no increased risks of adverse events or dropout rates in those taking omega-3 compared to control groups.
8
We investigated how eicosapentaenoic acid (EPA) affects heart rhythm, particularly in the context of high-fat diets. In our study, mice were divided into two groups: one received a high-fat diet, while the other’s diet was supplemented with EPA for eight weeks.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
We observed that the mice on a high-fat diet experienced severe heart rhythm issues, such as bradycardia and atrial fibrillation (AF). In contrast, the EPA group showed significantly less AF and better heart function. These results suggest that including EPA in the diet could be a promising strategy to support heart health and reduce the risk of arrhythmias.
7
We conducted a randomized clinical trial with 74 patients recovering from acute coronary syndrome (ACS) to see if Omega-3 supplementation could help reduce harmful heart rhythms. Participants received either a daily dose of 1 gram of Omega-3 or a placebo for five days, with their heart rhythms closely monitored using ECGs.
Our findings showed that Omega-3 fatty acids could potentially help manage arrhythmias, especially atrial fibrillation and some types of contractions. However, the treatment had minimal impact on more severe arrhythmias like ventricular tachycardia and fibrillation, indicating that more research is needed in this area.
Our findings showed that Omega-3 fatty acids could potentially help manage arrhythmias, especially atrial fibrillation and some types of contractions. However, the treatment had minimal impact on more severe arrhythmias like ventricular tachycardia and fibrillation, indicating that more research is needed in this area.
References
- Liepinsh E, Gukalova B, Krims-Davis K, Kuka J, Leduskrasta A, et al. EPA and DHA acylcarnitines are less cardiotoxic than are saturated and monounsaturated long-chain acylcarnitines. Biofactors. 2025;51:e70014. 10.1002/biof.70014
- Xu J, Peng T, Kong L, Wei N. A global analysis of the burden of ischemic heart disease attributable to diet low in ω-3 fatty acids between 1990 and 2021. BMC Cardiovasc Disord. 2025;25:188. 10.1186/s12872-025-04620-z
- Horii K, Ono K, Sumi T, Higashihara M, Zaima N, et al. Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice. J Physiol Sci. 2025;75:100014. 10.1016/j.jphyss.2025.100014
- Dawczynski C, Drobner T, Weidauer T, Schlattmann P, Kiehntopf M, et al. Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study. Lipids Health Dis. 2025;24:88. 10.1186/s12944-025-02500-1
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. 10.1161/JAHA.124.038656
- Tseng PT, Zeng BY, Hsu CW, Liang CS, Stubbs B, et al. The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis. Adv Nutr. 2025;16:100366. 10.1016/j.advnut.2025.100366
- Hemmati R, Bahrami Zanjanbar D, Shishesaz MI, Soleimani A, Yari T. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial. J Complement Integr Med. 2025;22:173. 10.1515/jcim-2024-0427
- Wang Y, Wu G, Wang Y, Rehman A, Yu L, et al. Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases. Food Chem. 2025;470:142498. 10.1016/j.foodchem.2024.142498
- Jawad MA, O'Keefe JH, Tintle N, O'Keefe EL, Franco WG, et al. Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities. Mayo Clin Proc. 2024;99:1895. 10.1016/j.mayocp.2024.08.007
- Lee YQ, Tan KH, Chong MF. Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review. Br J Nutr. 2024;132:1474. 10.1017/S0007114524002708
- Li J, Nan W, Huang X, Meng H, Wang S, et al. Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. EMBO Rep. 2024;25:5507. 10.1038/s44319-024-00271-x
- Ryuno Y, Kobayashi JI, Fujimoto Y, Dotare T, Matsue Y, et al. Effect of an Enteral Formula Enriched With ω-3 Fatty Acids, Carnitine, and Vitamin D on Body Weight, Heart Weight, and Blood Biochemical Parameters in a Dahl Rat Heart Failure Model. J Cardiovasc Pharmacol. 2024;84:590. 10.1097/FJC.0000000000001637
- Sun S, Hara A, Johnstone L, Hallmark B, Watkins JC, et al. Optimal Pair Matching Combined with Machine Learning Predicts a Significant Reduction in Myocardial Infarction Risk in African Americans Following Omega-3 Fatty Acid Supplementation. Nutrients. 2024;16. 10.3390/nu16172933
- Ahmadi M, Askari VR, Shahri B, Mousavi Noghab SM, Jarahi L, et al. Omega-3 fatty acids effectively mitigate high-sensitivity C-reactive protein (hs-CRP) biomarker of inflammation in acute myocardial infarction patients: a randomized, double-blind, placebo-controlled clinical trial. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:881. 10.1007/s00210-024-03330-1
- Chen HC, Tai CJ, Huang JY, Kuo TA, Huang YD, et al. Associations of fish oil with cardiovascular disease events: results from the Taiwan longitudinal study in aging. BMC Public Health. 2024;24:1979. 10.1186/s12889-024-19512-8
- Yu Y, Gao M, Xu H. Ginger Extract and Omega-3 Fatty Acids Supplementation: A Promising Strategy to Improve Diabetic Cardiomyopathy. Physiol Res. 2024;73:351.
